Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate
نویسندگان
چکیده
منابع مشابه
Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate.
The formation of oligodendrocytes (oligodendrogenesis) and myelin is regulated by several neurotrophic factors. Strategies to increase the level of these trophic molecules may facilitate repair in demyelinating conditions, such as multiple sclerosis (MS). Because leukocytes are a source of neurotrophic factors, and as glatiramer acetate (GA) generates T helper 2 (Th2) lymphocytes that are not k...
متن کاملTherapy with glatiramer acetate for multiple sclerosis.
BACKGROUND Some clinical data have shown that glatiramer acetate (Copaxone), a synthetic amino acid polymer empirically found to suppress experimental allergic encephalomyelitis (EAE), an animal model of MS, might help improve the outcome of patients with multiple sclerosis (MS). OBJECTIVES We performed a Cochrane review of all randomised, placebo-controlled trials of glatiramer acetate in MS...
متن کاملGlatiramer acetate in the treatment of multiple sclerosis
Glatiramer acetate is a synthetic, random copolymer widely used as a first-line agent for the treatment of relapsing-remitting multiple sclerosis (MS). While earlier studies primarily attributed its clinical effect to a shift in the cytokine secretion of CD4+ T helper (T(h)) cells, growing evidence in MS and its animal model, experimental autoimmune encephalomyelitis (EAE), suggests that glatir...
متن کاملGlatiramer acetate desensitisation in multiple sclerosis patients - the case report
Methods The 38-year-old woman with a diagnosis of MS was examined from April until July 2013 at the Allergology Unit, Department of Internal Medicine and Gastroenterology. In the absence of specific IgE tests against GA, a basophil activation test (BAT) was performed with a borderline result (GA concentration 1.0 ul/ml with 7.8% activated basophils, stimulation index 2.1). Then followed the GA ...
متن کاملSpasticity in multiple sclerosis and role of glatiramer acetate treatment
INTRODUCTION Spasticity is one of the most disabling and difficult-to-treat symptoms shown by patients with multiple sclerosis, who often show a suboptimal and unsatisfactory response to classic treatment and new available nonpharmacological alternatives. Due to the progressive nature of this condition, the early management should be essential to improve long-term outcomes. METHODS We perform...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0909607106